What is the use of Obeticholic Acid 5 mg?

It is used as a first-line or add-on therapy for PBC to help regulate bile acid production and improve liver function.

Is 5 mg the maintenance dose?

It is usually the starting dose; the maintenance dose may be increased to 10 mg based on clinical response.

Is it safe for patients with liver impairment?

Yes, 5 mg (or every other day) is used in moderate to severe hepatic impairment, but under close monitoring.

Can it be used with UDCA?

Yes, it is commonly used in combination with Ursodeoxycholic Acid (UDCA) for better outcomes.

Can this tablet be crushed?

No, the tablet should be swallowed whole unless otherwise directed.

Obeticholic Acid 5mg Tablets – Liver Support for PBC | Intralife Pharmaceuticals

Name: OBTIME-5
Brand: Intralife
SKU: -NzIExHsI2O7RMyVtGoE
Price: 2500 INR
Availability: InStock

OBTIME-5

MRP: 2,500

Packaging: 10x10

Pack Type: tablet

Composition:

Obeticholic Acid 5 mg

Indication:

Severe Acute Hepatitis, Bile Acid Diarrhoea, Bariatric And Gallstone Diseases

Description:

Obeticholic Acid 5 mg is a semi-synthetic bile acid analog used for the treatment of Primary Biliary Cholangitis (PBC) in adults, particularly in those who have an inadequate response to or are intolerant of ursodeoxycholic acid (UDCA). It acts by activating the farnesoid X receptor (FXR), which plays a crucial role in regulating bile acid synthesis and secretion.

By modulating FXR, Obeticholic Acid reduces the production and accumulation of toxic bile acids, decreasing liver inflammation and fibrosis, and improving overall liver function. The 5 mg dose is often used as the starting dose, especially in patients with hepatic impairment.

Tags:

Liver Support FXR Agonist Prescription Drug Bile Acid Regulator Chronic Liver Disease PBC Management

Usage Information

Dosage

Starting dose: 5 mg once daily May be increased to 10 mg once daily after 3 months based on patient response and tolerance Patients with moderate to severe hepatic impairment should remain on 5 mg every other day or as advised Always administer under physician supervision

Side Effects

Pruritus (itching) – most common adverse effect Fatigue, abdominal discomfort, rash, or nausea Liver enzyme elevations — requires regular monitoring Rare: hepatic decompensation in advanced cirrhosis

Contraindications

Decompensated cirrhosis (Child-Pugh Class B or C) Complete biliary obstruction Known hypersensitivity to Obeticholic Acid Caution advised in patients with prior liver transplant or advanced liver disease