INTRATOL
MRP: 5,985
Packaging: 10x1x4
Pack Type: tablet
Composition:
Tolvaptan 15mg
Indication:
In Treatment of Low levels of sodium in the blood, Low levels of sodium may be caused due to multiple reasons such as excess of body fluids, heart disease.
Description:
Tolvaptan 15 mg** is a vasopressin V2 receptor antagonist used to treat conditions involving fluid retention and low sodium levels, primarily:
Hyponatremia (low blood sodium) associated with Syndrome of Inappropriate Antidiuretic Hormone Secretion - SIADH, heart failure, or cirrhosis.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) to slow kidney function decline and reduce kidney volume.
Tolvaptan promotes aquaresis—excretion of free water without electrolyte loss—by blocking vasopressin activity, thereby increasing serum sodium levels and managing fluid overload.
Tags:
- Corrects low sodium levels (hyponatremia)
- Reduces kidney cyst growth in ADPKD
- Slows progression of kidney disease
- Helps manage fluid overload in SIADH
- Improves symptoms like fatigue and confusion related to sodium imbalance
Usage Information
Dosage
Hyponatremia: Initial dose: 15 mg once daily, may be increased to 30–60 mg based on response ADPKD: Typically starts with 45 mg in the morning and 15 mg in the afternoon; adjusted by physician Take with or without food Ensure adequate hydration to avoid dehydration Monitor serum sodium and liver function during treatment.
Side Effects
Common: Thirst Increased urination Dry mouth Fatigue Dizziness Serious: Liver injury (elevated ALT/AST) Dehydration and electrolyte imbalance Excessive sodium correction (osmotic demyelination risk) Hypotension
Contraindications
Anuria (inability to urinate) Impaired liver function or history of liver toxicity with tolvaptan Hypovolemic hyponatremia Inability to sense or respond to thirst Concomitant use of strong CYP3A inhibitors (e.g., ketoconazole, ritonavir)