INTRAPAM-CL-1000
MRP: 1,590
Packaging: 1gm
Pack Type: injection
Composition:
Imipenem 500mg + Cilastatin 500mg
Indication:
Septicaemia, Meningitis, Pneumonia & Bronchitis, Gynaecological & Obstetric Infection, Intra Abdominal Infection, Urinary Tract Infection.
Description:
Imipenem + Cilastatin Injection is a combination of two components:
Imipenem (500mg): A broad-spectrum carbapenem antibiotic that kills a wide range of Gram-positive and Gram-negative bacteria by inhibiting bacterial cell wall synthesis.
Cilastatin (500mg): Prevents the breakdown of imipenem in the kidneys by inhibiting the enzyme dehydropeptidase-I, increasing its efficacy and duration.
This injectable formulation is used to treat moderate to severe bacterial infections such as sepsis, pneumonia, urinary tract infections (UTIs), intra-abdominal infections, and joint, skin, or gynecologic infections. It is only administered under hospital supervision via intravenous (IV) infusion.
Tags:
- Broad-spectrum activity against resistant Gram-positive and Gram-negative bacteria
- Cilastatin protects imipenem from renal degradation
- Highly effective in ICU and emergency cases like sepsis and hospital-acquired infections
- Suitable for intra-abdominal, gynecological, joint, and respiratory infections
- Rapid action when administered intravenously
Usage Information
Dosage
Adults: 500mg/500mg every 6 to 8 hours IV (based on infection severity) Max Daily Dose: Typically up to 4g/day Pediatrics: Adjusted dose based on weight and clinical need Renal Impairment: Dose must be adjusted according to creatinine clearance Administered via IV infusion over 20–30 minutes For hospital use only under medical supervision
Side Effects
Nausea, vomiting Diarrhea Skin rash or itching Injection site pain Seizures (rare, mainly in renal impairment) Low blood pressure Elevated liver enzymes or abnormal blood counts Important: Regular renal function and CNS monitoring are advised during prolonged use.
Contraindications
Known hypersensitivity to Imipenem, Cilastatin, or other beta-lactam antibiotics History of seizures or CNS disorders Severe renal impairment (use with caution and dosage adjustment) Not intended for outpatient or self-use
Availability
Imipenem cilastatin 500mg injection Carbapenem antibiotic for infection Imipenem cilastatin IV uses Severe infection treatment injection Imipenem + cilastatin side effects Broad-spectrum IV antibiotic Hospital-use only antibiotics Imipenem cilastatin dosage and precautions